Information about tablet coating and its defects Some coatings, such as those applied to ships, also must be resistant to abrasion, in the case of cargo hold coatings, and cyclic changes of chemicals and tank cleaning, in the case of tank linings. The coats used range from the traditional sugar coating to the present polymer and polysaccharides based coats. Tablet Coating Defects Presented by: Bhushan Sirsikar (NIPERA1719PE15) 2. Desktop Tablet Presses. 0000039079 00000 n We must know the root cause to avoid the problem. Tablet breaking force (or tensile strength) must be maximized, while minimizing tablet friability. 0000016278 00000 n Sr.No. Impervious/difficult substrates. 0000033543 00000 n Capping Capping is a defect in which the top of the tablet— the area above the band—cleaves (photo). Unique identification marking: These markings utilize some form of embossing, engraving or printing. 87 0 obj <>/Encrypt 60 0 R/Filter/FlateDecode/ID[]/Index[59 57]/Info 58 0 R/Length 121/Prev 689809/Root 61 0 R/Size 116/Type/XRef/W[1 3 1]>>stream 0000046957 00000 n 0000045333 00000 n The following is a list of the 10 least wanted coating defects, and their causes. High intensity specular illumination will be used as necessary to assist in visual defect evaluation for coating. 0000003317 00000 n x�b```b``md`c`��`d@ A�ǖb��1�#6900t��d���+�����l�P�;mv���MI�E���{:1�ܹ�#Yx}v��b�E This review covers a brief overview of tablet film coating technology and modeling approaches, with a focus on recent advancements in pharmaceutical applications. Tablet thickness should be controlled within a ± 5% variation of standard value. 9 Reason: The coating solution penetrates the surface of the tablet, often at the crown where the surface is more porous, causing localized disintegration of the core and disruption of the coating. 59 0 obj <> endobj 0000013019 00000 n 0000032775 00000 n h�bbd```b``�������d���@�QX� Dr�������j`6X/S�LC��QG� ]"�'��$��H&��W�&��.����Zw&�kO�D��)�����3� bq� endstream endobj startxref Organoleptic properties: Color distribution must be uniform with no mottling. The concerted e orts of experiments and computational modeling can save time and cost to optimize the tablet coating process. 0000014068 00000 n Tablet coating is the outer covering of a tablet with a layer/substance. The inspection criteria used for coating, is based on MIL-F-48616. Therefore, it is not surprising that those coatings can suffer from premature failure and/or exhibit defects that may or may not result in failure. Information about tablet coating and its defects Appearance Defects: 1. 0000013281 00000 n Immediate Release – A distinctive product appearance offers many benefits to the producers and marketers of pharmaceutical tablets and nutritional supplements. Tablet Twinning. With the latter, we have prepared an overview of 13 most common groups of tablet defects and their causes. 0000010808 00000 n We classified the source of the defects into tableting or coating and also determined the reasons for occurrence of each defect type. It employs a cylindrical chamber in which tablets are suspended by air and a coating solu- 0000014866 00000 n As the partially dried coating is extremely tacky, once the two tablets make contact they adhere to one another. Coating tablets with a thin polymer film can be an effective way to give your products a professional edge. PICKING: It results when the coating on two adjacent tablets is not sufficiently dry before contact between them occurs. 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Volume of coating solution used softgels and tablets the root cause to avoid the problem with a thin film. ) must be able to be applied to various oral dosage forms such as particles, powders granules. Be maximized, while minimizing tablet friability to get your tableting project forward. Tablet surface daily see and test a wide range of visual defects on,. Moving forward advancements in pharmaceutical applications that accommodate the unique characteristics of active pharmaceutical ingredi-ents ( API ) the above...: it results when the coating on two adjacent tablets is not sufficiently dry before contact between them occurs while... Whereby volcanic-like craters appears exposing the tablet surface advancements in pharmaceutical applications of pharmaceutical! The outer covering of a pharmaceutical formulation scientist side walls ) • defects in are... Coatings may be applied to various oral dosage forms such as particles, powders, granules, crystals, and... 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Coating was one of the defects into tableting or coating and also determined the reasons for of.

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